Gastroprotective properties of 11-deoxymisoprostol (prostaglandin E1 analog) and its effect on the level of sialic acids in gastric tissue of rats with peptic ulcer

11-Deoxymisoprostol (prostaglandin E1 analog) exhibited a pronounced gastroprotective effect on various models of experimental ulcers induced by nonsteroid antiinflammatory drugs. A relationship between high resistance of the gastroduodenal mucosa under the effect of 11-deoxymisoprostol and changes...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-10, Vol.142 (4), p.467-469
Main Authors: Baschenko, N Zh, Sapozhnikova, T A, Gabdrakhmanova, S F, Makara, N S, Khisamutdinova, R Yu, Zarudii, F S, Ivanova, N A, Nazarov, V S
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Anti-Ulcer Agents - pharmacology
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Male
Misoprostol - analogs & derivatives
Misoprostol - pharmacology
Peptic Ulcer - chemically induced
Peptic Ulcer - drug therapy
Peptic Ulcer - metabolism
Rats
Rats, Wistar
Sialic Acids - metabolism
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Summary:11-Deoxymisoprostol (prostaglandin E1 analog) exhibited a pronounced gastroprotective effect on various models of experimental ulcers induced by nonsteroid antiinflammatory drugs. A relationship between high resistance of the gastroduodenal mucosa under the effect of 11-deoxymisoprostol and changes in the level of sialic acid was detected.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0394-7