Comparative study of pharmacological activity of afala on the model of hormone-induced prostatitis in rats

Afala (ultralow-dose antibodies to prostate-specific antigen) injected for 60 days to rats with hormone-induced prostatitis caused by sulpiride prevented the development of prostatic hyperplasia and reduced the severity of histological changes. The effect of Afala was superior to that of the referen...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2007-11, Vol.144 (5), p.699-701
Main Authors: Savelieva, K V, Borovskaya, T G, Kheyfets, I A, Dugina, J L, Sergeeva, S A, Epstein, O I
Format: Article
Language:English
Subjects:
Animals
Antibodies - immunology
Antibodies - pharmacology
Disease Models, Animal
Immunoenzyme Techniques
Male
Organ Size - drug effects
Plant Extracts - pharmacology
Prolactin - blood
Prostate - drug effects
Prostate - pathology
Prostate-Specific Antigen - immunology
Prostatic Hyperplasia - blood
Prostatic Hyperplasia - chemically induced
Prostatic Hyperplasia - drug therapy
Prostatitis - blood
Prostatitis - chemically induced
Prostatitis - drug therapy
Rats
Serenoa - chemistry
Sulpiride
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Summary:Afala (ultralow-dose antibodies to prostate-specific antigen) injected for 60 days to rats with hormone-induced prostatitis caused by sulpiride prevented the development of prostatic hyperplasia and reduced the severity of histological changes. The effect of Afala was superior to that of the reference drug (Serenoa repens extract).
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0409-z