Toxic effect of single treatment with bromantane on neurological status of experimental animals

• Published in: Bulletin of experimental biology and medicine 2002-04, Vol.133 (4), p.380
• Main Authors: Iezhitsa, I N, Spasov, A A, Bugaeva, L I, Morozov, I S
• Format: Article
• Language: English
• Subjects: Amantadine - analogs & derivatives; Amantadine - toxicity; Animals; Behavior, Animal - drug effects; Dose-Response Relationship, Drug; Female; Lethal Dose 50; Male; Nervous System - drug effects; Rats
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1023/A:1016206306875

Neurotoxicological profile of actoprotector bromantane was studied on rats using S. Irwin's protocol of multi-test observation. The drug in doses of 30-300 mg/kg stimulated and in doses of 600-9,600 mg/kg suppressed behavioral activity. Spontaneous motor activity increased after single treatment with bromantane in doses of 30-300 mg/kg, did not change after treatment in doses of 600 mg/kg, and was inhibited after treatment in doses above 600 mg/kg. In doses of 300-600 mg/kg the drug reduced pain sensitivity threshold and in doses above 600 mg/kg elevated the pain threshold and tactile sensitivity and reaction to knock. Bromantane induced mydriasis in all studied doses; in doses above 10 g/kg the preparation induced blepharoptosis. In doses above 5 g/kg bromantane slightly increased respiration rate and depth (Kussmaul-like respiration). In some animals bromantane in high doses induced regurgitation, diarrhea, and polyuria. Rectal temperature decreased by 0.5-1 degrees C after virtually all doses. Behavioral effects of bromantane in doses of 30 and 600 mg/kg were associated with stimulation of the central dopamine and suppression of muscarinic and nicotinic cholinergic structures, n-cholinolytic effects of bromantane was more pronounced at a dose of 30 mg/kg than at a dose of 600 mg/kg.