Perftoran as a means modulating the functional activity of liver macrophages

Experiments on mice showed that perfluorocarbon emulsion Perftoran modulated phagocytic activity of liver macrophages (evaluated by LD50 for Salmonella typhi endotoxin and the rate of elimination of Chinese ink particles from the bloodflow). Phagocytic activity was suppressed for 3 days after inject...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-12, Vol.134 (6), p.551
Main Authors: Kovelenov, A Yu, Mikhal'tsov, A N, Malkov, A N
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Animals
Blood Substitutes - pharmacology
Blood Substitutes - therapeutic use
Carbon
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - prevention & control
Coloring Agents - pharmacokinetics
Fluorocarbons - pharmacology
Fluorocarbons - therapeutic use
Kupffer Cells - drug effects
Kupffer Cells - metabolism
Lethal Dose 50
Liver - cytology
Mice
Phagocytosis - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Experiments on mice showed that perfluorocarbon emulsion Perftoran modulated phagocytic activity of liver macrophages (evaluated by LD50 for Salmonella typhi endotoxin and the rate of elimination of Chinese ink particles from the bloodflow). Phagocytic activity was suppressed for 3 days after injection of 10 mg/kg emulsion, but then increased above the control. Perftoran had a favorable impact on the course of experimental hepatitis in a model experiment based on hyperactivity of Kupffer cells. Perftoran virtually prevented the development of severe hepatitis after prophylactic injection and notably attenuated hepatocyte cytolysis when used as therapeutic mean.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1022905027083