The Leading Role of Membrane Ca2+-ATPase in Recovery of Ca2+ Homeostasis after Glutamate Shock

Combined blockade of Na(+)/Ca(2+) exchange, Ca(2+) uptake by mitochondria and endoplasmic reticulum usually does not prevent recovery of the basal level of intracellular Ca(2+) after 1-min action of glutamate (100 microM) or K(+) (50 mM). However, replacement of Ca(2+) with Ba(2+), which cannot be t...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-02, Vol.135 (2), p.139
Main Authors: Storozhevykh, T P, Pinelis, V G, Vinskaya, N P, Surin, A M, Khodorov, B I
Format: Article
Language:English
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Summary:Combined blockade of Na(+)/Ca(2+) exchange, Ca(2+) uptake by mitochondria and endoplasmic reticulum usually does not prevent recovery of the basal level of intracellular Ca(2+) after 1-min action of glutamate (100 microM) or K(+) (50 mM). However, replacement of Ca(2+) with Ba(2+), which cannot be transported by Ca(2+)-ATPase, considerably delayed the decrease in intracellular Ba(2+) after its rise caused by glutamate or potassium application in all examined cells, which attest to an important role of Ca(2+)-ATPase in Ca(2+) extrusion after the action of glutamate or K(+).
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1023811613109