Effect of mitomycin C on distribution of chromatid exchanges and their dose dependency in resting human lymphocytes

Cells distribution by the number of chromatid exchanges induced by mitomycin C corresponds to geometric distribution. The dependences of the number of chromatid exchanges and the number of fragments on the dose of the mutagen are described by exponential and linear curves, respectively. Quantitative...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-06, Vol.133 (6), p.600
Main Authors: Kosyakova, N V, Chebotarev, A N
Format: Article
Language:English
Subjects:
Alkylating Agents - pharmacology
Cells, Cultured
Dose-Response Relationship, Drug
Humans
Mitomycin - pharmacology
Mutagens - pharmacology
Resting Phase, Cell Cycle
Sister Chromatid Exchange - drug effects
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Summary:Cells distribution by the number of chromatid exchanges induced by mitomycin C corresponds to geometric distribution. The dependences of the number of chromatid exchanges and the number of fragments on the dose of the mutagen are described by exponential and linear curves, respectively. Quantitative regularities of mitomycin C-induced chromosome aberrations correspond to those of "monocentric" mutagens.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1020202413330