Protective effect of calcium channel blocker verapamil on morphological and functional state of hair cells of the organ of corti in experimental kanamycin-induced ototoxicity

The protective effect of verapamil against acute ototoxic sensorineural damage produced by intraperitoneal injections of kanamycin (50 mg/kg daily for 14 day) was studied on rats. The functional (otoacoustic emission), histological, and physiological methods proved the protective effect of daily inj...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-04, Vol.133 (4), p.404
Main Authors: Zhuravskii, S G, Lopotko, A I, Tomson, V V, Ivanov, A G, Chomskii, A N, Nurskii, K V
Format: Article
Language:English
Subjects:
Animals
Calcium Channel Blockers - pharmacology
Deafness - chemically induced
Kanamycin - toxicity
Male
Organ of Corti - cytology
Organ of Corti - drug effects
Organ of Corti - physiology
Rats
Verapamil - pharmacology
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Summary:The protective effect of verapamil against acute ototoxic sensorineural damage produced by intraperitoneal injections of kanamycin (50 mg/kg daily for 14 day) was studied on rats. The functional (otoacoustic emission), histological, and physiological methods proved the protective effect of daily injections of calcium channel blocker verapamil (2 mg/kg) on the state of hair cells of the organ of Corti.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1016222810509