Pathogenetic role of dysbacteriosis in the development of complications of type 1 diabetes mellitus in children

A relationship between enteric microbiocenosis and severity of type 1 diabetes mellitus was detected. Microbiological analysis showed II-IV degree dysbacteriosis in all diabetic children. Long-term therapy with probiotics aimed at eradication of opportunistic microflora resulted in recovery of micro...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-02, Vol.133 (2), p.164
Main Authors: Rozanova, G N, Voevodin, D A, Stenina, M A, Kushnareva, M V
Format: Article
Language:English
Subjects:
Adolescent
Bacterial Infections - physiopathology
Child
Child, Preschool
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - microbiology
Diabetes Mellitus, Type 1 - physiopathology
Humans
Intestinal Diseases - microbiology
Intestinal Diseases - physiopathology
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Summary:A relationship between enteric microbiocenosis and severity of type 1 diabetes mellitus was detected. Microbiological analysis showed II-IV degree dysbacteriosis in all diabetic children. Long-term therapy with probiotics aimed at eradication of opportunistic microflora resulted in recovery of microbiocenosis, which was paralleled by improvement of the clinical status, regression of complications in children who were ill for a long time, and prevention of complications in children with newly detected diabetes. These results indicate the leading role of chronic enteric toxic infectious process in the development of complications of type 1 diabetes. The significance of infection in the pathogenesis of other noninfectious diseases in man is discussed.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1015503006854