Effect of potentiated antibodies to morphine on behavioral reactions in rats with morphine dependence

We studied the effect of potentiated antibodies to morphine (10(-100) wt %) on self-stimulation of the lateral hypothalamus and behavioral reactions reflecting the severity of withdrawal syndrome in rats with morphine dependence. Repeated treatment with potentiated antibodies to morphine increased t...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003, Vol.135 Suppl 7, p.34
Main Authors: Vorob'eva, T M, Berchenko, O G, Geiko, V V, Kolyadko, S P, Bevzyuk, D A, Pan, I R, Epstein, O I
Format: Article
Language:English
Subjects:
Animals
Antibodies - pharmacology
Behavior, Animal - drug effects
Brain - drug effects
Brain - metabolism
Male
Morphine - antagonists & inhibitors
Morphine - immunology
Morphine Dependence
Rats
Self Stimulation - drug effects
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Summary:We studied the effect of potentiated antibodies to morphine (10(-100) wt %) on self-stimulation of the lateral hypothalamus and behavioral reactions reflecting the severity of withdrawal syndrome in rats with morphine dependence. Repeated treatment with potentiated antibodies to morphine increased the rate of self-stimulation, suppressed active avoidance response, promoted freezing behavior after acoustic stimulation, and decreased tail-flick latency in rats after morphine withdrawal. Distilled water did not produce these changes.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1024776614368