Antimutagenic and antioxidant activities of crown compounds in comparison with the effects of garlic extract

Antimutagenic activity of N-carboxyalkyl derivatives of aza- and benzoazacrown compounds was revealed and antimutagenic activity of garlic extract was confirmed. Specific genoprotective effect of crown compounds towards the effects of various mutagens was demonstrated. The antimutagenic effect of th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-03, Vol.135 (3), p.261
Main Authors: Zasukhina, G D, Vasil'eva, I M, Mikhal'chik, E S, Durnev, A D, Gromov, S P, Fedorova, O A, Alfimov, M V
Format: Article
Language:English
Subjects:
Antimutagenic Agents - metabolism
Antimutagenic Agents - pharmacology
Antioxidants - metabolism
Antioxidants - pharmacology
Cell Line
Crown Ethers - metabolism
Crown Ethers - pharmacology
DNA - drug effects
DNA Damage
Garlic - chemistry
Humans
Leukocytes - cytology
Leukocytes - drug effects
Plant Extracts - metabolism
Plant Extracts - pharmacology
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Summary:Antimutagenic activity of N-carboxyalkyl derivatives of aza- and benzoazacrown compounds was revealed and antimutagenic activity of garlic extract was confirmed. Specific genoprotective effect of crown compounds towards the effects of various mutagens was demonstrated. The antimutagenic effect of these compounds was not realized via antioxidant mechanisms, while the protective effect of garlic extract was associated with its antioxidant and reparative activities.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1024137031398