Effect of carnosine on immunocompetent cells from alcoholic patients

We studied the effect of natural dipeptide carnosine on phagocytosis, respiratory burst in neutrophils, and subpopulation composition of lymphocytes from healthy donors and alcoholic patients. Carnosine in vitro produced different effects on immunocompetent cells from healthy donors and patients wit...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-09, Vol.138 (3), p.255-258
Main Authors: Nevidimova, T I, Prokop'eva, V D, Naidenova, N N, Tyulina, O V, Bokhan, N A
Format: Article
Language:English
Subjects:
Alcoholism - immunology
Carnosine - pharmacology
Humans
Lymphocytes - drug effects
Neutrophils - drug effects
Phagocytosis - drug effects
Reactive Oxygen Species - analysis
Respiratory Burst - drug effects
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Summary:We studied the effect of natural dipeptide carnosine on phagocytosis, respiratory burst in neutrophils, and subpopulation composition of lymphocytes from healthy donors and alcoholic patients. Carnosine in vitro produced different effects on immunocompetent cells from healthy donors and patients with alcoholism. In patients with alcoholism phagocytic activity of leukocytes and generation of reaction oxygen species increased under the influence of carnosine in a concentration of 0.01 mM, but decreased after treatment with this compound in a concentration of 1 mM. Carnosine in both concentrations stimulated the respiratory burst, but had no effect on the count of phagocytic cells in healthy donors. Carnosine in a concentration of 0.01 mM increased the number of lymphocytes carrying apoptosis markers (CD95+) in patients with alcoholism not receiving therapy. Our results indicate that carnosine holds much promise for the therapy of alcoholism.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0014-y