Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice

We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginin...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-02, Vol.137 (2), p.111-113
Main Authors: Lobanov, A V, Rzhevskii, D I, Korshunov, V A, Murashev, A N
Format: Article
Language:eng ; rus
Subjects:
Adrenergic Antagonists - pharmacology
Animals
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - metabolism
Arrhythmias, Cardiac - prevention & control
Atenolol - pharmacology
Atropine - pharmacology
Cholinergic Antagonists - pharmacology
Endothelin-1 - pharmacology
Hexamethonium - pharmacology
Male
Mice
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide - biosynthesis
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Summary:We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginine in NMRI mice. Atropine reduced, while hexamethonium completely abolished the arrhythmogenic effect of endothelin-1 during nitric oxide synthase inhibition. Atenolol potentiated arrhythmogenic activity of Nomega-nitro-L-arginine, but endothelin-1 had no effect on the incidence of arrhythmias under these conditions.
ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000028115.53995.e0