Gonadotoxic effect of polychlorobiphenyls

The distribution of polychlorobiphenyls (environmental pollutants) in the reproductive organs and fatty tissues of rats was analyzed and selective accumulation of the toxicants in the epididymis, but not in the ovaries, was demonstrated. Reduction of the fertilizing activity of the ejaculate after c...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-07, Vol.146 (1), p.70-72
Main Authors: Gromenko, D. S., Galimov, Sh. N., Amirova, Z. K., Abdullina, A. Z., Gromenko, Yu. Yu, Galimova, E. F.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Environmental Pollutants - toxicity
Female
Fertility - drug effects
Genitalia - drug effects
Internal Medicine
Laboratory Medicine
Male
Pathology
Pharmacology and Toxicology
Polychlorinated Biphenyls - toxicity
Pregnancy
Rats
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Summary:The distribution of polychlorobiphenyls (environmental pollutants) in the reproductive organs and fatty tissues of rats was analyzed and selective accumulation of the toxicants in the epididymis, but not in the ovaries, was demonstrated. Reduction of the fertilizing activity of the ejaculate after chronic exposure to polychlorobiphenyls was detected. Mechanisms of spermatogenic dysfunction under conditions of high technogenic load are discussed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0206-3