Diabetes, obesity, and the brain

Recent evidence suggests a key role for the brain in the control of both body fat content and glucose metabolism. Neuronal systems that regulate energy intake, energy expenditure, and endogenous glucose production sense and respond to input from hormonal and nutrient-related signals that convey info...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2005-01, Vol.307 (5708), p.375-379
Main Authors: Schwartz, M.W, Porte, D. Jr
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Anatomy
Animals
blood glucose
Body fat
Brain
Brain - metabolism
carbohydrate metabolism
Care and treatment
Causes of
Complications and side effects
Diabetes
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Eating
Energy
Energy Metabolism
Fatty Acids, Nonesterified - metabolism
Food intake
Glucose
Glucose - metabolism
Health aspects
Homeostasis
Humans
Hypothalamus - metabolism
Insulin
Insulin - metabolism
Insulin Resistance
Leptin - genetics
Leptin - metabolism
Lipodystrophy - physiopathology
Metabolism
Models, Biological
Neurons
Neurons - physiology
noninsulin-dependent diabetes mellitus
Obesity
Obesity - etiology
Obesity - metabolism
Obesity - physiopathology
Physiological aspects
Receptor, Insulin - metabolism
Signal Transduction
Type 2 diabetes
Type 2 diabetes mellitus
Viewpoints
Weight gain
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Description
Summary:Recent evidence suggests a key role for the brain in the control of both body fat content and glucose metabolism. Neuronal systems that regulate energy intake, energy expenditure, and endogenous glucose production sense and respond to input from hormonal and nutrient-related signals that convey information regarding both body energy stores and current energy availability. In response to this input, adaptive changes occur that promote energy homeostasis and the maintenance of blood glucose levels in the normal range. Defects in this control system are implicated in the link between obesity and type 2 diabetes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1104344