PS-097 Adult Survivors Of Fetal Anaemia Have Increased Cardiovascular Risk: Findings From A Cohort Study Of Intrauterine Transfusion Recipients

• Published in: Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A145
• Main Authors: Wallace, AH, Dalziel, SR, Cowan, B R, Young, A A, Thornburg, K L, Harding, JE
• Format: Article
• Language: English
• Subjects: Adenosine; Adults; Anemia; Anthropometry; Birth weight; Blood flow; Blood pressure; Body Weight; Cardiovascular diseases; Cohort analysis; Fetuses; Health risks; Heart rate; High density lipoprotein; Lipids; Magnetic resonance imaging; Scientific Concepts; Sympathetic nervous system; Transfusion; Ventricle
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2014-307384.392

BackgroundIn sheep, intrauterine anaemia causes increased susceptibility to ischaemic injury in adulthood, but effects on humans are unknown. The aim of this study was to investigate cardiovascular outcome in adults who received intrauterine transfusion for fetal anaemia due to rhesus disease.MethodsParticipants were adults who received intrauterine transfusion and their unaffected sibling (s). Assessments included anthropometry, blood pressure, lipids, heart rate variability and cardiac MRI. Analysis was by multiple regression adjusted for age, sex, and birth weight z-score, with data as adjusted means ± SD (95% CI).ResultsCompared to unaffected siblings, affected participants had smaller ventricular volumes, for example end diastolic volume indexed to body surface area (EDV/BSA); reduced high density lipoprotein (HDL); increased heart rate variability low frequency/high frequency (LF/HF) ratio indicating augmented sympathetic tone; and lower myocardial blood flow (MBF) at rest and with cold pressor stress, but not during adenosine infusion, indicating impaired endothelial function.Abstract PS-097 Table 1 Affected(n = 95)Unaffected(n = 92)p-valueAge (years)33.7 ± 9.340.1 ± 10.9