PO-0672 Cord Blood Osteocalcine, Leptin And Tnf? Levels In Gestational Diabetic Pregnancies

AimTo compare cord blood osteocalcin, leptin and TNF α levels in gestational diabetic and normal pregnancies.Method191 deliveries were included in this research. 41 (21.5%) of pregnancies were gestational diabetic and 159 (78.5%) of pregnancies were normal. Cord blood osteocalcin, leptin and TNF α l...

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Bibliographic Details
Published in:Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A474-A474
Main Authors: Dalkan, C, Uncu, M, Galip, N, Yayci, EYUP, Bahceciler, N, Akman, I
Format: Article
Language:English
Subjects:
Blood glucose
Cord blood
Diabetes
Diabetes mellitus
Gestation
Glucose
Hypoglycemia
Hypothyroidism
Insulin
Insulin secretion
Leptin
Osteocalcin
Ponderal index
Pregnancy
Pregnancy complications
Secretion
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Summary:AimTo compare cord blood osteocalcin, leptin and TNF α levels in gestational diabetic and normal pregnancies.Method191 deliveries were included in this research. 41 (21.5%) of pregnancies were gestational diabetic and 159 (78.5%) of pregnancies were normal. Cord blood osteocalcin, leptin and TNF α levels were compared.ResultsThere was no significant difference among birth weights (p:0.409), heights (p:0.07), head circumferences (p 0.201), gender (p:0.4), gestational weeks (p:0.201), ponderal index (0.564) between groups. There was no significant difference between groups regarding pregnancy complications. However, hypothyroidism was more common in gestational diabetic group (p:< 0.001). In addition, hypoglycemia was more common in gestational diabetic group (p:0.047).Gestational diabetic group’s cord blood osteocalcin levels were higher than in non diabetic group (p:0.037). Cord blood TNF α (p:0.813) and leptin average levels (p: 0,212) were not statistically different. Osteocalcin, leptin and TNF α levels were not statistically different between boys and girls.DiscussionOsteocalcin; originating from bones, increases insulin sensitivity in peripheral organs and insulin secretion. Leptin is known to inhibit insulin and osteocalcin secretion. Osteocalcin level increase in gestational diabetic group, may be related to osteocalcin regulation of blood glucose levels. Cord blood leptin and TNF α levels showed no significant difference between groups, probably due to proper regulation of cord blood glucose levels during gestation.
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2014-307384.1313