O-124 Human Milk Cream Enhances Growth When Supplementing Standard Fortification Of An Exclusive Human Milk-based Diet In Vlbw Infants

• Published in: Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A72
• Main Authors: Hair, AB, Blanco, CL, Hawthorne, K M, Moreira, A G, Lee, M L, Rechtman, D J, Abrams, SA
• Format: Article
• Language: English
• Subjects: Breast milk; Control Groups; Cream; Demography; Diet; Donors; Infants; Milk; Sepsis; Velocity; Young Children
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2014-307384.191

BackgroundThe use of an exclusively human milk (HM)-based diet lowers the incidence of NEC, however concerns exist regarding adequate growth. Frequently, donor and maternal HM have a low caloric content. A HM cream -derived supplement can increase the caloric density of an exclusive HM-based diet.ObjectiveDetermine if premature infants fed an exclusive HM-based diet and a HM cream-derived supplement (Cream) would have equal growth compared to infants fed a standard feeding regimen (Control).MethodsIn a prospective randomised study, infants with BW 750–1250 grams (g) were assigned to a dietary group. All infants received mother’s own milk or donor HM, with donor HM-derived fortifier. Cream group also received a HM-derived cream supplement if the HM tested < 20 kcal/oz (infrared HM analyzer). F/U continued until 36 weeks PMA. Primary outcomes included growth velocities and incidences of NEC and sepsis. Non-inferiority was established if the lower bound of weight velocity exceeded -3 g/kg/day.ResultsThere were no differences in demographics exceptrace (p = 0.02). Theone-sided 95% lower bound of the confidence interval for the difference in meanvelocity (cream-control) was 0.38 g/kg/day.Abstract O-124 Table 1Comparison of growth velocitiesParameterCream group n = 39(mean ±SD)Control group n = 39(mean ±SD)p-value (two sample t-test with unequal variances)Length velocity (cm/wk)1.03 ± 0.330.83 ± 0.410.02Head circumference (cm/wk)0.90 ± 0.190.84 ± 0.220.21Weight velocity (g/kg/day)14.0 ± 2.512.4 ± 3.90.03Weight velocity from regained BW (g/kg/day)15.7 ± 2.513.7 ± 4.00.02ConclusionsCream group infants had better weight and length velocity. HM cream-derived supplement should be considered as a supplement to an exclusive HM-based diet.