PO-0183 Role Of Oral Corticosteroids Before Admission In Infants With Acute Moderately Ill Bronchiolitis

Background and aimsCurrent evidence does not support a clinically relevant effect of systemic glucocorticoids in reducing length of hospitalisation (LOS) in acute bronchiolitis. To evaluate whether treatment with oral corticosteroids prior to admission (CO) decreases LOS in patients admitted for acu...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A306-A306
Main Authors: Flores-Gonzalez, JC, Comino-Vazquez, P, Serrano-Moyano, B, Palma-Zambrana, E, Grujic, B, Estalella-Mendoza, A, Calvo-Morales, IM, Garofano-Montero, S, Rodriguez-Campoy, P, Perez-Guerrero, JJ, Garcia-Ortega, RM, Garcia-Garcia, L, Dávila-Corrales, FJ, Lechuga-Sancho, AM
Format: Article
Language:English
Subjects:
Atopy
Breast feeding
Bronchopneumonia
Brucellosis
Clinical trials
Corticoids
Corticosteroids
Glucocorticoids
Hospitals
Infants
Infections
Oxygen
Oxygen saturation
Patients
Pediatrics
Respiration
Respiratory syncytial virus
Risk factors
Salbutamol
Sepsis
Smoking
Statistical analysis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and aimsCurrent evidence does not support a clinically relevant effect of systemic glucocorticoids in reducing length of hospitalisation (LOS) in acute bronchiolitis. To evaluate whether treatment with oral corticosteroids prior to admission (CO) decreases LOS in patients admitted for acute moderate bronchiolitis (MB).Material and methodsIn a context of a randomised, controlled, double-blind clinical trial, 185 patients with MB were included and grouped in receiving CO before admission for more than 24 h or not. Patients who received corticosteroids during hospitalisation and patients with risk factors for severe bronchiolitis were excluded. LOS as the main variable was recorded. Secondary: clinical scale, respiratory rate and oxygen saturation on admission.Results26.5% received corticosteroids before to admission. Demographic and clinical data were similar (p > 0.05): Males (47% vs 51%), exclusively breastfeeding (51% vs 56%), or RSV positive (61% vs 60%), parental smoking (45% vs 39%) and atopy (38% vs 28%). There were statistically significant differences in mean age (3.5 vs 1.7 months, p = 0.000), severity clinical scale (5,37 vs 4.93 points, p = 0.021) and in receiving salbutamol (85.7% vs 19.1%, p = 0.000). There was no difference in respiratory rate (p = 0.584) or oxygen saturation on admission (p = 0.07). The LOS was 2.43 vs 3.22 days, p = 0.004.ConclusionsIn our series, CO administration before admission to BA decreases LOS significantly. The CO group was older but more severe; both can be a confusion factor.
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2014-307384.844