PO-0266 Septic Shock Secondary To A Community Acquired Infection: About 51 Cases

• Published in: Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A332-A332
• Main Authors: Mahdoui, S, Tilouche, S, Tej, A, Soyah, N, Missaoui, N, Kahloul, N, Mlika, A, Bouguila, J, Boughamoura, L
• Format: Article
• Language: English
• Subjects: Attrition (Research Studies); Bacteria; Catecholamines; Cefotaxime; Children; Community Relations; Developing countries; Dopamine; Epidemiology; Gram-negative bacteria; Infections; LDCs; Mechanical ventilation; Morbidity; Mortality; Neonates; Norepinephrine; Patients; Sepsis; Septic shock; Ventilation
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2014-307384.920

IntroductionSeptic shock in children remains one of the main causes of morbidity and mortality worldwide. Although their diagnosis and their management is largely influenced by studies done in adults. There are important considerations relevant for paediatrics.GoalThis study had for aim to evaluate epidemiology and outcome of septic shock secondary to a community acquired infection.Patients and methodsA retrospective analysis was made of patients admitted between January 2004 and December 2013, in a paediatric department for septic shock secondary to a community-acquired infection. Neonates were excluded from the study.ResultsFifty-one cases were included. The average age was 2.7 years (1 month–14 years). The average time between the observation of first disease symptoms and admission was 2.8 days (1–14 days). The average PRISM during the first 24 h was 20.3 (4–41). Multiple organ failure was present in the majority of cases (96%). Gram-negative bacteria were the predominant pathogens (50%). Respiratory infection is the most common infection site (37.3%). The empiric therapy was a combination of Cefotaxime and Aminoglycoside in 52.9% of cases. Dopamine remains the most prescribed catecholamine (72.5%). Dobutamine and Norepinephrine were used in 62.7% and 31.4% of cases. Mechanical ventilation was needed in 39 patients with an average of 2.8 days (1–16 days). The average length of hospitalisation was 12.6 ± 6.9 days (4–30 days). The mortality was 70.6%.ConclusionDespite significant progress in the understanding and treatment, septic shock continues to be a major health problem in developing countries and around the world.