association between thiazolidinediones and hospitalisation for fracture in type 2 diabetic patients: a Taiwanese population-based nested case-control study

Aims/hypothesis Evidence from the USA has emerged that thiazolidinediones may have a negative effect on the skeleton and increase the risk of fracture, but the association between thiazolidinediones use and fractures has not been evaluated in an Asian population. Using the 2000-2005 Taiwan National...

Full description

Saved in:
Bibliographic Details
Published in:Diabetologia 2010-03, Vol.53 (3), p.489-496
Main Authors: Hsiao, F.-Y, Mullins, C. D
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Case-Control Studies
Cohort Studies
Diabetes Complications - pathology
Diabetes Mellitus, Type 2 - pathology
Diabetes. Impaired glucose tolerance
Dose-Response Relationship, Drug
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Fractures, Bone - chemically induced
Fractures, Bone - epidemiology
Human Physiology
Humans
Internal Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Multivariate Analysis
Taiwan
Thiazolidinediones - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims/hypothesis Evidence from the USA has emerged that thiazolidinediones may have a negative effect on the skeleton and increase the risk of fracture, but the association between thiazolidinediones use and fractures has not been evaluated in an Asian population. Using the 2000-2005 Taiwan National Health Insurance claims database, this Taiwanese population-based nested case-control study explored the association between thiazolidinediones use and hospitalisation for bone fracture in type 2 diabetic patients. Methods In the study cohort of type 2 diabetic patients, we identified 18,003 patients with fracture and 90,015 matched controls. Multivariable conditional logistic regressions were used to estimate the association between exposure to thiazolidinediones and fractures. Duration of thiazolidinediones use was defined on the basis of cumulative days of exposure to thiazolidinediones during the year prior to the index date, i.e. 180 days. Results More type 2 diabetic patients with fractures than controls used thiazolidinediones (fractures 5.99% vs control 4.06%). Thiazolidinediones use was associated with hospitalisation for fracture and the association was stronger with longer term exposure to thiazolidinediones (
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-009-1609-z