The synthesis and spectroscopic characterisation of 3‐formyl‐2‐quinolones in the presence of biothiols

The derivatives of 3‐formyl‐2(1H)‐quinolones and N‐methyl‐3‐formyl‐2‐quinolones substituted in the 6‐position with either a methyl or a methoxy group were synthesised and evaluated as potential sensors for the detection of thiol amino acids. Their spectroscopic properties, including absorption and e...

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Bibliographic Details
Published in:Coloration technology 2018-12, Vol.134 (6), p.440-449
Main Authors: Grzelakowska, Aleksandra, Kolińska, Jolanta, Mąkiewicz, Mariusz
Format: Article
Language:English
Subjects:
Amino acids
Cysteine
Emission spectra
Fluorescence
Selectivity
Sensors
Spectroscopy
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Summary:The derivatives of 3‐formyl‐2(1H)‐quinolones and N‐methyl‐3‐formyl‐2‐quinolones substituted in the 6‐position with either a methyl or a methoxy group were synthesised and evaluated as potential sensors for the detection of thiol amino acids. Their spectroscopic properties, including absorption and emission spectra, fluorescence quantum yields and singlet lifetimes, were examined. The behaviour of the obtained compounds was studied at pH 7.4 in the presence of various amino acids. The results show that these compounds demonstrate a high turn‐off fluorescence response and selectivity toward L‐cysteine in the presence of other amino acids, and have the potential to act as sensors to L‐cysteine.
ISSN:1472-3581
1478-4408
DOI:10.1111/cote.12355