Microfluidics: an Untapped Resource in Viral Diagnostics and Viral Cell Biology

Purpose of Review Microfluidic platforms have become valuable tools in a wide variety of research environments. With the ability to allow detailed examination of an array of cell biological processes, their use in the field of virology is becoming progressively more common. This review will discuss...

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Bibliographic Details
Published in:Current clinical microbiology reports 2018-12, Vol.5 (4), p.245-251
Main Authors: Simpson, Caitlin, Lee, Sung Sik, Lee, Chang-Soo, Yamauchi, Yohei
Format: Article
Language:English
Subjects:
Biology
Biomedical and Life Sciences
Biomedicine
Drug screening
Infectivity
Life cycles
Medical Microbiology
Microfluidics
Section Editor
Topical Collection on Virology
Virology
Virology (A Nicola
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Summary:Purpose of Review Microfluidic platforms have become valuable tools in a wide variety of research environments. With the ability to allow detailed examination of an array of cell biological processes, their use in the field of virology is becoming progressively more common. This review will discuss the potential applications of microfluidics in viral cell biology and explore the potential of these techniques to alter the way in which we study the biology of infection. Recent Findings In recent years, scientists have utilised microfluidic platforms for detailed study of the viral life cycle. Microfluidic technologies have allowed investigation of viral infectivity, measurement of fusion kinetics, and monitoring of viral responses to neutralising compounds. In addition, microfluidic platforms represent promising new clinical tools with applications in diagnostics and drug screening. Summary Although the potential of microfluidics in virology is beginning to be realised, it has certainly not been fully explored. While not a replacement for macroscale investigative techniques, microfluidic platforms have the potential to be utilised alongside systems biology to provide novel methods of detailed virus study, with unique advantages.
ISSN:2196-5471
2196-5471
DOI:10.1007/s40588-018-0105-y