Sharply Increased Serum Free Light-Chain Concentrations after Treatment for Multiple Myeloma/Commentary/Commentary

By her next follow-up appointment a month later, the patient had completed 2 full cycles of the lenalidomide and dexamethasone regimen and showed evidence of continued response, as evidenced by a rise in the hemoglobin concentration to 105 g/L and a decrease in urinary protein excretion to 132 mg/24...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2010-01, Vol.56 (1), p.16
Main Authors: Murata, Kazunori, Clark, Raynell J, Lockington, Karen S, Tostrud, Linda J, Greipp, Philip R, Katzmann, Jerry A, Faix, Jim D, Blinder, Morey A
Format: Article
Language:English
Subjects:
Bone marrow
Light
Medical imaging
Medicine
Multiple myeloma
Plasma
Proteins
Urine
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Summary:By her next follow-up appointment a month later, the patient had completed 2 full cycles of the lenalidomide and dexamethasone regimen and showed evidence of continued response, as evidenced by a rise in the hemoglobin concentration to 105 g/L and a decrease in urinary protein excretion to 132 mg/24 h. The patient's serumκ FLC concentration remained increased at 1500 mg/L, however. Examination of the bone marrow reveals bone marrow involvement by plasma cells, which constitute >10% of all nucleated cells in 96% of MMpatients; this finding is confirmatory forMM.Laboratory findings at the time of diagnosis include anemia (73% of patients), increased serum creatinine (50%), hypercalcemia (28%), and leukopenia (20%). [...] falsely low serum FLC results may be obtained in cases of antigen excess (6).
ISSN:0009-9147
1530-8561