Influence of thyroid hormone autoantibodies on 7 thyroid hormone assays

Spurious results of thyroid function tests (TFT) can be recognized when they do not reflect the clinical status of the patient or are not internally consistent [e.g., increased FT4 with nonsuppressed thyroidstimulating hormone (TSH)]. Potential causes of spurious TFT results include nonspecific bind...

Full description

Saved in:
Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2008-05, Vol.54 (5), p.927-928
Main Authors: Zouwail, Soha A, O'Toole, Angela M, Clark, Penelope M S, Begley, Joe P
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Cross Reactions
False Negative Reactions
False Positive Reactions
Hormones
Humans
Hypothyroidism
Male
Methods
Polyethylene glycol
Reagents
Thyroid
Thyroid Function Tests
Thyroid gland
Thyrotropin - blood
Thyrotropin - immunology
Thyroxine - blood
Thyroxine - immunology
Triiodothyronine - blood
Triiodothyronine - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spurious results of thyroid function tests (TFT) can be recognized when they do not reflect the clinical status of the patient or are not internally consistent [e.g., increased FT4 with nonsuppressed thyroidstimulating hormone (TSH)]. Potential causes of spurious TFT results include nonspecific binding of endogenous circulating factors?, such as heterophilic antibodies, with assay reagents (1), the presence of albumin variants found in familial dysalbuminemic hyperthyroxinaemia (2), and thyroid hormone autoantibodies (THAA) (3).
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2007.099770