Use of Capillary Zone Electrophoresis for Differentiating Excessive from Moderate Alcohol Consumption

The poorly sialylated transferrin isoforms in serum were analyzed by capillary zone electrophoresis (CZE) to differentiate moderate from heavy alcohol consumption. We enrolled 614 volunteers, classified after interviews, self-reported drinking habits, and AUDIT scores as alcohol abusers (consuming &...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2003-03, Vol.49 (3), p.440-449
Main Authors: Legros, Franz J, Nuyens, Vincent, Baudoux, Michel, Zouaoui Boudjeltia, Karim, Ruelle, Jean-Luc, Colicis, Jacques, Cantraine, Francis, Henry, Jean-Pol
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alcohol Drinking
Alcoholism - diagnosis
Alcohols
Asialoglycoproteins - analysis
Biological and medical sciences
Biomarkers - blood
Capillary zone
Diagnosis, Differential
Electrophoresis
Electrophoresis, Capillary
Ethanol
Female
Humans
Immunoassay
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Metabolic diseases
Middle Aged
Nephelometry and Turbidimetry
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Protein Isoforms
ROC Curve
Sex Factors
Silica
Transferrin - analogs & derivatives
Transferrin - analysis
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Summary:The poorly sialylated transferrin isoforms in serum were analyzed by capillary zone electrophoresis (CZE) to differentiate moderate from heavy alcohol consumption. We enrolled 614 volunteers, classified after interviews, self-reported drinking habits, and AUDIT scores as alcohol abusers (consuming >50 g/day ethanol for the previous 3 months or longer; n = 413) or moderate drinkers (
ISSN:0009-9147
1530-8561
DOI:10.1373/49.3.440