A Strong Interaction between Serum {gamma}-Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey

Some studies have found an association of obesity with type 2 diabetes only among individuals with high normal serum γ-glutamyltransferase (GGT) activity, not in those with low serum GGT. If this interaction reflected pathophysiology, it would have scientific and clinical importance. The findings fa...

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Published in:Clinical chemistry (Baltimore, Md.) Md.), 2007-06, Vol.53 (6), p.1092
Main Authors: Lim, Ji-Sun, Lee, Duk-Hee, Park, Joo-Yun, Jin, Soo-Hee, Jacobs, David R., Jr
Format: Article
Language:English
Subjects:
Behavior
Cardiovascular disease
Diabetes
Ethnicity
Hyperglycemia
Minority & ethnic groups
Obesity
Physical examinations
Plasma
Risk factors
Smoking
Studies
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container_title Clinical chemistry (Baltimore, Md.)
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creator Lim, Ji-Sun
Lee, Duk-Hee
Park, Joo-Yun
Jin, Soo-Hee
Jacobs, David R., Jr
description Some studies have found an association of obesity with type 2 diabetes only among individuals with high normal serum γ-glutamyltransferase (GGT) activity, not in those with low serum GGT. If this interaction reflected pathophysiology, it would have scientific and clinical importance. The findings failed to reach statistical significance, however, and no articles have focused on the topic. We investigated possible interactions between serum GGT and body mass index (BMI) and their effects on the risk of prevalent type 2 diabetes and homeostasis model assessment (HOMA) insulin resistance. We analyzed 4011 adults ≥40 years old who participated in the 3rd US National Health and Nutrition Examination Survey. BMI was associated with prevalent diabetes only among persons with high normal serum GGT activity (P for interaction = 0.002). In the highest serum GGT quartile, adjusted odds ratios for BMI 25-29.9, 30-34.5, and ≥35 kg/m^sup 2^ compared with BMI≤25 kg/m^sup 2^ were 3.1, 5.1, and 6.2, respectively (P for trend
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If this interaction reflected pathophysiology, it would have scientific and clinical importance. The findings failed to reach statistical significance, however, and no articles have focused on the topic. We investigated possible interactions between serum GGT and body mass index (BMI) and their effects on the risk of prevalent type 2 diabetes and homeostasis model assessment (HOMA) insulin resistance. We analyzed 4011 adults ≥40 years old who participated in the 3rd US National Health and Nutrition Examination Survey. BMI was associated with prevalent diabetes only among persons with high normal serum GGT activity (P for interaction = 0.002). In the highest serum GGT quartile, adjusted odds ratios for BMI 25-29.9, 30-34.5, and ≥35 kg/m^sup 2^ compared with BMI≤25 kg/m^sup 2^ were 3.1, 5.1, and 6.2, respectively (P for trend &lt;0.001). In the lowest serum GGT quartile, BMI was not associated with diabetes; corresponding adjusted odds ratios were 1.0, 0.9, 1.8, and 0.8 (P for trend = 0.551). After prevalent diabetes was excluded, there was a parallel interaction with HOMA levels (P for interaction &lt;0.001). BMI was not associated with prevalent type 2 diabetes when GGT was low normal, suggesting that obesity itself may not be a sufficient risk factor for type 2 diabetes. 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subjects Behavior
Cardiovascular disease
Diabetes
Ethnicity
Hyperglycemia
Minority & ethnic groups
Obesity
Physical examinations
Plasma
Risk factors
Smoking
Studies
title A Strong Interaction between Serum {gamma}-Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey
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