Hyaluronic acid-modified [19F]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs

In this study, we designed and synthesized [ 19 F]FDG-(2-deoxy-2-[fluorine-19]fluoro- d -glucose) conjugated iron oxide magnetic nanoparticles ([ 19 F]FDG-MNPs) for hybrid imaging and hyperthermia treatment. MNPs were synthesized, silica coated, and fabricated with TEOS (tetraethyl orthosilicate). T...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2018-12, Vol.318 (3), p.1973-1989
Main Authors: Yasakci, Volkan, Tekin, Volkan, Guldu, Ozge Kozgus, Evren, Vedat, Unak, Perihan
Format: Article
Language:English
Subjects:
Bioavailability
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Fluorine
Hadrons
Heavy Ions
Hyaluronic acid
Hyperthermia
In vivo methods and tests
Inorganic Chemistry
Iron oxides
Nanoparticles
Nuclear Chemistry
Nuclear Physics
Organs
Physical Chemistry
Silicon dioxide
Synthesis
Tetraethyl orthosilicate
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Summary:In this study, we designed and synthesized [ 19 F]FDG-(2-deoxy-2-[fluorine-19]fluoro- d -glucose) conjugated iron oxide magnetic nanoparticles ([ 19 F]FDG-MNPs) for hybrid imaging and hyperthermia treatment. MNPs were synthesized, silica coated, and fabricated with TEOS (tetraethyl orthosilicate). They were then covered with hyaluronic acid (HA) to enhance their bioavailability. The modified MNPs were conjugated with [ 19 F]FDG and optically labeled with ICG (indocyanine green). The in vitro bioaffinities were surveyed in MCF7 and PC3 cell lines. In vivo bioaffinies were determined using Sprague–Dawley rats.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-018-6282-6