Effect of Naproxen on Renal Haemodynamics in Elderly Patients with Arthritis

The effects of naproxen on renal haemodynamics were observed in ten elderly arthritic patients who were otherwise healthy and without clinical evidence of renal disease. Glomerular filtration rate (GFR,51Cr-EDTA clearance) and effective renal plasma flow (ERPF, 125I-iodohippurate clearance) were mea...

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Bibliographic Details
Published in:Age and ageing 1989-01, Vol.18 (1), p.26-30
Main Authors: WALLIS, P. J. W., LODWICK, R., SINHA, S. K., CONSTABLE, T. J.
Format: Article
Language:English
Subjects:
Adverse and side effects
Age Factors
Aged
Aged, 80 and over
Arthritic persons
Arthritics
Arthritis
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - physiopathology
Care and treatment
Drugs
Female
Glomerular Filtration Rate - drug effects
Humans
Male
Medical research
Naproxen
Naproxen - adverse effects
Naproxen - pharmacology
Older people
Osteoarthritis - drug therapy
Osteoarthritis - physiopathology
Random Allocation
Renal artery
Renal Circulation - drug effects
Urology
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Summary:The effects of naproxen on renal haemodynamics were observed in ten elderly arthritic patients who were otherwise healthy and without clinical evidence of renal disease. Glomerular filtration rate (GFR,51Cr-EDTA clearance) and effective renal plasma flow (ERPF, 125I-iodohippurate clearance) were measured after 2 weeks' treatment with naproxen 500 mg twice daily and again after 2 weeks off the drug, in random order. Baseline values for GFR and ERPF were within normal limits (mean 72 ml/min/1.73 m2, 110° predicted and 326 ml/min/1.73 m2, 111° predicted, respectively). On naproxen, ERPF and renal blood flow decreased by 10° and 9°, respectively (−32 ml/min/1.73 m2; p=0.05 and −49 ml/min/1.73 m2; p
ISSN:0002-0729
1468-2834
DOI:10.1093/ageing/18.1.26