Effects of Bicyclol on Liver Regeneration After Partial Hepatectomy in Rats

• Published in: Digestive diseases and sciences 2009-04, Vol.54 (4), p.774-781
• Main Authors: Yao, Xiao-Min, Zhao, Jing, Li, Yue, Li, Yan
• Format: Article
• Language: English
• Subjects: Alanine Transaminase - blood; Animals; Bilirubin - blood; Biochemistry; Biological and medical sciences; Biphenyl Compounds - pharmacology; Biphenyl Compounds - therapeutic use; Cell Proliferation; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Gastroenterology; Glutathione - metabolism; Glycogen - metabolism; Hepatectomy; Hepatocytes - metabolism; Hepatology; Liver - enzymology; Liver - pathology; Liver Diseases - pathology; Liver Diseases - prevention & control; Liver Regeneration - drug effects; Liver, biliary tract, pancreas, portal circulation, spleen; Male; Malondialdehyde - metabolism; Medical sciences; Medicine; Medicine & Public Health; Mitotic Index; Oncology; Original Article; Proliferating Cell Nuclear Antigen - metabolism; Rats; Rats, Sprague-Dawley; Superoxide Dismutase - metabolism; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Transplant Surgery; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-009-0715-6

Bicyclol is a synthetic antihepatitis drug with antioxidative property. The present study was performed to investigate the effect of bicyclol on liver regeneration after partial hepatectomy in rats. Bicyclol (300 mg/kg) was given to rats subjected to 70% hepatectomy three times before operation. At 6, 24, and 48 h after resection, samples were collected for the measurement of serum alanine aminotransferase (ALT), total bilirubin (TBil), hepatic glycogen, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH). Moreover, liver regeneration rate, proliferating cell nuclear antigen (PCNA) labeling, proliferation index, and histopathological examination were evaluated at 48 h after hepatectomy. As a result, bicyclol significantly increased regeneration rate, mitotic index (MI), PCNA labeling index, and proliferation index in PH rats. Additionally, bicyclol remarkably inhibited the elevation of serum ALT and TBil levels, alleviated the formation of liver MDA, restored impaired antioxidant SOD and GSH, increased hepatic glycogen content, and also attenuated hepatic vacuolar degeneration. These results suggested that bicyclol had a beneficial effect on liver regenerative capacity of the remnant liver tissue after hepatectomy, probably due to its antioxidative property.