Gastric mucosal blood flow regulation in response to different stimuli

We compared changes in gastric mucosal blood flow (GMBF) and left gastric artery blood flow (LGABF) in response to pharmacological, physiological, and pathological stimuli. GMBF and LGABF were measured by the hydrogen gas clearance and perivascular ultrasonic transit time techniques, respectively, u...

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Bibliographic Details
Published in:Digestive diseases and sciences 1997-09, Vol.42 (9), p.1873-1879
Main Authors: MENDEZ, A, CASADEVALL, M, WACHTER, C. H, ELIZALDE, J. I, DEL RIVERO, M, HEINEMANN, A, HOLZER, P, QUINTERO, E, PIQUE, J. M
Format: Article
Language:English
Subjects:
Anemia - physiopathology
Animals
Arteries - diagnostic imaging
Biological and medical sciences
Female
Gastric Acid - metabolism
Gastric Mucosa - blood supply
Gastroenterology. Liver. Pancreas. Abdomen
Hemodilution
Hydrogen
Hyperemia - chemically induced
Hyperemia - physiopathology
Male
Medical sciences
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - physiology
Other diseases. Semiology
Pentagastrin - pharmacology
Rats
Rats, Sprague-Dawley
Regional Blood Flow - drug effects
Regional Blood Flow - physiology
Stomach - blood supply
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Taurocholic Acid - pharmacology
Ultrasonography
Vasoconstrictor Agents - pharmacology
Vasopressins - pharmacology
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Summary:We compared changes in gastric mucosal blood flow (GMBF) and left gastric artery blood flow (LGABF) in response to pharmacological, physiological, and pathological stimuli. GMBF and LGABF were measured by the hydrogen gas clearance and perivascular ultrasonic transit time techniques, respectively, under baseline conditions and following intravenous infusion of vasopressin or pentagastrin, isovolemic hemodilution, or gastric perfusion with HCl-taurocholate. Blood flow changes following vasopressin or hemodilution were significantly larger in the left gastric artery than in the gastric mucosa. In contrast, the increment in blood flow associated with pentagastrin-stimulated acid secretion was significantly greater in the gastric mucosa than in the extramural artery. Barrier disruption with acid-taurocholate induced similar changes in both measurement sites. The gastric hyperemia induced by either mechanism was significantly attenuated by blockade of NO synthesis. These data demonstrate that although functional changes in GMBF are primarily supported by changes in blood flow at the extramural gastric arteries, the gastric mucosal microvasculature is also under the influence of independent local control mechanisms.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1018807009266