Influence of menthol on caffeine disposition and pharmacodynamics in healthy female volunteers

• Published in: European journal of clinical pharmacology 2003-09, Vol.59 (5-6), p.417-422
• Main Authors: GELAL, Ayse, GUVEN, Hulya, BALKAN, Dilara, ARTOK, Levent, BENOWITZ, Neal L
• Format: Article
• Language: English
• Subjects: Administration, Oral; Adolescent; Adult; Area Under Curve; Biological and medical sciences; Caffeine - blood; Caffeine - pharmacokinetics; Caffeine - pharmacology; Coffee; Cross-Over Studies; Cytochrome P-450 CYP1A2 - metabolism; Double-Blind Method; Drug Interactions; Female; General pharmacology; Half-Life; Heart Rate - drug effects; Humans; Medical sciences; Menthol - administration & dosage; Menthol - pharmacology; Middle Aged; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Time Factors
• ISSN: 0031-6970; 1432-1041
• DOI: 10.1007/s00228-003-0631-1

The present study was undertaken to determine whether a single oral dose of menthol affects the metabolism of caffeine, a cytochrome P(450) 1A2 (CYP1A2) substrate, and pharmacological responses to caffeine in people. Eleven healthy female subjects participated in a randomized, double-blind, two-way crossover study, comparing the kinetics and effects of a single oral dose of caffeine (200 mg) in coffee taken together with a single oral dose of menthol (100 mg) or placebo capsules. Serum caffeine concentrations and cardiovascular and subjective parameters were measured throughout the study. Co-administration of menthol resulted in an increase of caffeine t(max) values from 43.6+/-20.6 min (mean+/-SD) to 76.4+/-28.0 min ( P