Changes in urinary PGE2 after ibuprofen treatment in preterm infants with patent ductus arteriosus

Purpose To investigate changes in urinary PGE 2 after ibuprofen treatment in preterm infants with patent ductus arteriosus (PDA). Methods Twenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6 ± 2.3 weeks) and 20 controls (gestational age, 30.4 ± 1.5 weeks) were prospec...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2009-03, Vol.65 (3), p.223-230
Main Authors: Antonucci, R., Cuzzolin, L., Arceri, A., Dessì, A., Fanos, V.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Clinical outcomes
Clinical Trial
Clinical trials
Congenital diseases
Creatinine - blood
Dinoprostone - urine
Drug therapy
Ductus Arteriosus, Patent - drug therapy
Female
Humans
Ibuprofen - adverse effects
Ibuprofen - therapeutic use
Infant, Newborn
Infant, Premature
Infusions, Intravenous
Male
Medical sciences
Nonsteroidal anti-inflammatory drugs
Pharmacology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Premature birth
Prospective Studies
Urinalysis
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Summary:Purpose To investigate changes in urinary PGE 2 after ibuprofen treatment in preterm infants with patent ductus arteriosus (PDA). Methods Twenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6 ± 2.3 weeks) and 20 controls (gestational age, 30.4 ± 1.5 weeks) were prospectively enrolled at 48–72 h of life. After enrollment, the former underwent conventional ibuprofen-lysine treatment. At 48–72 h (T 0 ) and 108–144 h of life (T 1 ), urine samples were noninvasively collected in both groups to measure urinary PGE 2 concentrations (enzyme immunoassay method), and renal function was investigated. Results Urinary PGE 2 decreased significantly both in ibuprofen-treated patients (66.95 ± 16.78 vs. 27.15 ± 17.92 pg/mL, P  
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-008-0586-3