Ibuprofen arginate provides effective relief from postoperative dental pain with a more rapid onset of action than ibuprofen

Ibuprofen is a safe and effective analgesic, but some formulations have a slow onset of action. Ibuprofen arginate is a rapidly absorbed salt designed to promote more rapid onset of analgesia. A clinical trial was conducted in 226 patients with postoperative dental pain to assess the analgesic effic...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2002-09, Vol.58 (6), p.387-394
Main Authors: Desjardins, Paul, Black, Peter, Papageorge, Maria, Norwood, Tom, Shen, Danny D, Norris, Lonnie, Ardia, Alfredo
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - blood
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arginine - adverse effects
Arginine - blood
Arginine - therapeutic use
Double-Blind Method
Drug Combinations
Female
Humans
Ibuprofen - adverse effects
Ibuprofen - blood
Ibuprofen - therapeutic use
Male
Oral Surgical Procedures
Pain, Postoperative - drug therapy
Pain, Postoperative - etiology
Time Factors
Tooth Extraction
Treatment Outcome
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Summary:Ibuprofen is a safe and effective analgesic, but some formulations have a slow onset of action. Ibuprofen arginate is a rapidly absorbed salt designed to promote more rapid onset of analgesia. A clinical trial was conducted in 226 patients with postoperative dental pain to assess the analgesic efficacy and speed of onset of the arginine salt of ibuprofen compared with one of the commercially available forms of ibuprofen. Patients were administered a single dose of either ibuprofen arginate (200 mg or 400 mg), ibuprofen (200 mg or 400 mg), or placebo in this double-blind, randomized trial. To determine the onset of action of the study medication patients were required to note time to "any" pain relief and then time to "meaningful" pain relief, using the two-stopwatch method. Pain intensity and relief were assessed using traditional categorical scales over a 6-h period. Meaningful pain relief was achieved in 42 min and 24 min for ibuprofen arginate 200 mg and 400 mg, respectively, compared with 50 min and 48 min for ibuprofen 200 mg and 400 mg, respectively ( P
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-002-0491-0