A catheter-based radiation detector for endovascular detection of atheromatous plaques

Although various radiopharmaceuticals have been developed for the detection of atheromas, external imaging techniques have limitations when it comes to the detection of small plaques. In this study, we developed a charged particle-sensitive detector for the endovascular detection of small plaques. T...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2004-09, Vol.31 (9), p.1299
Main Authors: Mukai, Takahiro, Nohara, Ryuji, Ogawa, Mikako, Ishino, Seigo, Kambara, Naoshige, Kataoka, Kazuaki, Kanoi, Toru, Saito, Kazuhiro, Motomura, Hiroshi, Konishi, Junji, Saji, Hideo
Format: Article
Language:English
Subjects:
Animals
Carotid Stenosis - diagnostic imaging
Catheterization - instrumentation
Coronary Artery Disease - diagnostic imaging
Equipment Design
Equipment Failure Analysis
Fluorodeoxyglucose F18
Humans
Phantoms, Imaging
Radiation Dosage
Radiometry - instrumentation
Radiometry - methods
Radionuclide Imaging
Radiopharmaceuticals
Reproducibility of Results
Scintillation Counting - instrumentation
Scintillation Counting - methods
Sensitivity and Specificity
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Summary:Although various radiopharmaceuticals have been developed for the detection of atheromas, external imaging techniques have limitations when it comes to the detection of small plaques. In this study, we developed a charged particle-sensitive detector for the endovascular detection of small plaques. The device consists of a probe, an automatic pullback unit and a controller. The probe, which consists of a plastic scintillator and flexible optical fibres, is 1.0 mm in diameter. The probe was inserted into a catheter placed on (18)F point sources, and then the radioactivity was measured as the probe was pulled out stepwise. The sensitivity for (18)F was 9.3 cps/kBq, and there was a close linear correlation between the peak counts and source dose until at least 0.8 MBq. Furthermore, this device showed low background counts (
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-004-1574-1