Association Between High.Dose Spironolactone and Decongestion in Patients with Acute Heart Failure: An Observational Retrospective Study

[...]the reduction in NT-proBNP was significant in both groups, suggesting that in the rigorous randomized setting of ATHENA-HF, the control group received aggressive care. 4.1 Study Limitations Due to the small number of patients included in our study, generalization of the results should be applie...

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Bibliographic Details
Published in:American journal of cardiovascular drugs : drugs, devices, and other interventions devices, and other interventions, 2018-10, Vol.18 (5), p.415-422
Main Authors: Kapelios, Chris J, Bonou, Maria, Vogiatzi, Paraskevi, Tzanis, George, Mantzouratou, Polyxeni, Lund, Lars H, Barbetseas, John
Format: Article
Language:English
Subjects:
Cardiology
Diuretics
Enzymes
Heart failure
Laboratories
Medical diagnosis
Mortality
Patients
Task forces
Urine
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Summary:[...]the reduction in NT-proBNP was significant in both groups, suggesting that in the rigorous randomized setting of ATHENA-HF, the control group received aggressive care. 4.1 Study Limitations Due to the small number of patients included in our study, generalization of the results should be applied with caution before confirmation is available from larger population analyses. [...]spironolactone was not administered to 30% of patients in the control group, based on treating physicians' team decision, for reasons pertaining to high serum potassium levels and impaired renal function. Patients with congestion were administered HPODS based on a single physicians' team clinical decision and routine practice. Since patients were randomly assigned to treating physicians' teams in the in-hospital setting, no differences in patients' baseline characteristics would be expected; this was indeed so. Nonetheless our study is limited by its observational, retrospective design.
ISSN:1175-3277
1179-187X
DOI:10.1007/s40256-018-0290-3