Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders

Autism spectrum disorder (ASD) is characterized by repetitive stereotypic behaviors, restricted interests, social withdrawal, and communication deficits. Aggression and insensitivity to pain are largely unexplained in these cases. We analyzed nine mRNA expressions of the candidate genes related to a...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2019, Vol.67 (1), p.89-96
Main Authors: Sener, Elif Funda, Taheri, Serpil, Sahin, Mustafa Caglar, Bayramov, Keziban Korkmaz, Marasli, Mert Kahraman, Zararsiz, Gokmen, Mehmetbeyoglu, Ecmel, Oztop, Didem Behice, Canpolat, Mehmet, Canatan, Halit, Ozkul, Yusuf
Format: Article
Language:English
Subjects:
Aggression
Autism
Autistic children
Biomedical and Life Sciences
Biomedicine
Blood
Cell Biology
Children
Dopamine D4 receptors
Gender
Gene expression
Genes
Genomes
Girls
Neurochemistry
Neurology
Neurosciences
Pain
Patients
Peripheral blood
Proteomics
Ribonucleic acid
RNA
Statistical analysis
Statistical methods
Stem cells
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Summary:Autism spectrum disorder (ASD) is characterized by repetitive stereotypic behaviors, restricted interests, social withdrawal, and communication deficits. Aggression and insensitivity to pain are largely unexplained in these cases. We analyzed nine mRNA expressions of the candidate genes related to aggression and insensitivity to pain in the peripheral blood of patients with ASD. Whole blood samples were obtained from 40 autistic patients (33 boys, 7 girls) and 50 age- and sex-matched controls (37 boys and 13 girls) to isolate RNA. Gene expression was assessed by quantitative Real-Time PCR (qRT-PCR) in the Erciyes University Genome and Stem Cell Center (GENKOK). All of the gene expressions except CRHR1 and SLC6A4 were found to be statistically different between the ASD patients and controls. Gene expression also differed according to gender. Alterations in the mRNA expression patterns of the HTR1E , OPRL1 , OPRM1 , TACR1 , PRKG1 , SCN9A and DRD4 genes provide further evidence for a relevant effect of the respective candidate genes on the pathophysiology of ASD. Future studies may determine the sensitivity of these candidate markers in larger samples including further neuropsychiatric diagnosis.
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-018-1213-0