An Integrated Lab‐on‐a‐chip Approach to Study Heterogeneous Enantioselective Catalysts at the Microscale

An integrated lab‐on‐a‐chip enables the rapid analysis of heterogenized enantioselective organocatalysis at the microscale. A packed‐bed microreactor was seamlessly integrated with a downstream chiral high pressure liquid chromatography (HPLC) functionality to study enantioselective transformations...

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Bibliographic Details
Published in:ChemCatChem 2018-12, Vol.10 (23), p.5382-5385
Main Authors: Warias, Rico, Zaghi, Anna, Heiland, Josef J., Piendl, Sebastian K., Gilmore, Kerry, Seeberger, Peter H., Massi, Alessandro, Belder, Detlev
Format: Article
Language:English
Subjects:
Asymmetric catalysis
Beads
Catalysis
Catalysts
Enantiomers
High performance liquid chromatography
Lab-on-a-chip
Liquid chromatography
Mass spectrometry
Microfluidics
Microreactors
Reagents
Selectivity
Substrates
Supported catalysis
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Summary:An integrated lab‐on‐a‐chip enables the rapid analysis of heterogenized enantioselective organocatalysis at the microscale. A packed‐bed microreactor was seamlessly integrated with a downstream chiral high pressure liquid chromatography (HPLC) functionality to study enantioselective transformations on a single microfluidic glass chip. Hyphenation to mass spectrometry allows for the rapid investigation of the selectivity and the substrate scope of microgram amounts of catalyst beads. Optimization of reaction conditions is possible with minimal reagent consumption and instant analytical feedback. A rock‐solid approach: Combining a packed bed microreactor and miniaturized HPLC on a single chip‐based device enables rapid insights into asymmetric heterogeneous catalysis while producing minimal waste and requiring only minute amounts of immobilized organocatalysts.
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.201801637