Comparative Characterization of Rat Strains (Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT, SHR, BD-IX) by Their Behavior, Hormonal Level and Antioxidant Status

The rat strains Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT (low CNS excitability threshold), SHR, BD-IX (“Biocollection of the Pavlov Institute of Physiology”) were comparatively screened for the indicators of hormonal and antioxidant status as well as behavior. In male rats, the following...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2018-09, Vol.54 (5), p.374-382
Main Authors: Rybnikova, E. A., Vetrovoi, O. V., Zenko, M. Yu
Format: Article
Language:English
Subjects:
Animal Physiology
Antioxidants
Anxiety
Biochemistry
Biomedical and Life Sciences
Comparative and Ontogenic Physiology
Corticosterone
Data processing
Dehydroepiandrosterone
Evaporation
Evolutionary Biology
Excitability
Life Sciences
Locomotor activity
Phenotyping
Physiology
Rodents
Testosterone
Thyroid
Thyroid-stimulating hormone
Thyroxine
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Summary:The rat strains Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT (low CNS excitability threshold), SHR, BD-IX (“Biocollection of the Pavlov Institute of Physiology”) were comparatively screened for the indicators of hormonal and antioxidant status as well as behavior. In male rats, the following characteristics were evaluated: behavioral (locomotor activity, anxiety level, depressive-like behavior in the Prosolt forced swim test), hormonal (corticosterone, dehydroepiandrosterone–DHEA, thyroid-stimulating hormone–TSH, thyroxine and testosterone levels) and blood antioxidative activity. Considering our data on physiological phenotyping the above rat strains, physiological maps were created for each strain and a specific descriptive biocollection format was elaborated to represent relevant information as a publicly available online resource ( http://hst5.infran.ru/biocollection/ ) which can be helpful in choosing an experimental object and instrumental in analyzing data obtained on certain rat strains.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093018050058