Obituary

While a graduate student at the Roswell Park Memorial Institute, Enzo and colleagues described evidence of DNA-dependent RNA polymerase activity in purified infectious vaccinia virus particles, one of the first indications of the relative molecular independence of poxviruses from host cells. A semin...

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Bibliographic Details
Published in:Vaccine 2018-10, Vol.36 (45), p.6579
Main Authors: Tine, John A, Taylor, Jill
Format: Article
Language:English
Subjects:
Company structure
Deaths
Deoxyribonucleic acid
DNA
DNA-directed RNA polymerase
Genomes
Laboratories
Nucleotide sequence
Ribonucleic acid
RNA
RNA polymerase
Vaccine development
Vaccines
Viruses
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Summary:While a graduate student at the Roswell Park Memorial Institute, Enzo and colleagues described evidence of DNA-dependent RNA polymerase activity in purified infectious vaccinia virus particles, one of the first indications of the relative molecular independence of poxviruses from host cells. A seminal achievement in the early years of Virogenetics was the determination of the complete DNA sequence of the Copenhagen vaccine strain of vaccinia virus, the first complete sequence of a poxvirus genome to be reported. The realities and economic complexities of vaccine development, licensure and manufacturing were at times in conflict with scientific goals, and these tensions led Enzo and the parent organization to part company in 1995.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2018.09.025