Effects of biventricular pacing on interstitial remodelling, tumor necrosis factor-[alpha] expression, and apoptotic death in failing human myocardium

Aims Recent data from the COMPANION trial have documented that cardiac resynchronization therapy (CRT) with biventricular (BiV) pacing reduces mortality and hospitalization in patients with advanced CHF, but little is known regarding the cellular and molecular mechanisms of CRT. Our aim is to evalua...

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Published in:European heart journal 2006-01, Vol.27 (2), p.201
Main Authors: Cristoforo D'Ascia, Cittadini, Antonio, Monti, Maria Gaia, Riccio, Giuseppe, Saccà, Luigi
Format: Article
Language:English
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Summary:Aims Recent data from the COMPANION trial have documented that cardiac resynchronization therapy (CRT) with biventricular (BiV) pacing reduces mortality and hospitalization in patients with advanced CHF, but little is known regarding the cellular and molecular mechanisms of CRT. Our aim is to evaluate interstitial remodelling, tumor necrosis factor-α (TNF-α) expression, and apoptosis in patients with advanced CHF treated with CRT. Methods and results We performed endomyocardial biopsies in 10 patients, aged 62, with dilated cardiomyopathy before and 6 months after the implantation of a BiV pacing device. Clinical status and left ventricular (LV) architecture and function were assessed as well as myocardial histology, TNF-α expression, and apoptotic index. CRT improved clinical status, as shown by a significant reduction of the Minnesota living with heart failure questionnaire (MLHFQ) score (from 53 to 40) and 6-min walked distance (from 290 to 330 m) (all P
ISSN:0195-668X
1522-9645