Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial

• Published in: European heart journal 2009-06, Vol.30 (11), p.1313-1321
• Main Authors: Tendera, Michał, Wojakowski, Wojciech, Rużyłło, Witold, Chojnowska, Lidia, Kępka, Cezary, Tracz, Wiesława, Musiałek, Piotr, Piwowarska, Wiesława, Nessler, Jadwiga, Buszman, Paweł, Grajek, Stefan, Bręborowicz, Piotr, Majka, Marcin, Ratajczak, Mariusz Z.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Angioplasty, Balloon, Coronary; Biological and medical sciences; Bone marrow progenitor cells; Bone Marrow Transplantation - methods; Cardiac Output, Low - therapy; Cardiology. Vascular system; Cardiovascular system; Coronary Angiography; Coronary heart disease; CXCR4+ cells; Drug Administration Schedule; Female; Heart; Humans; Intracoronary infusion; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Myocardial infarction; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Myocarditis. Cardiomyopathies; Prospective Studies; Research Design; Stroke Volume; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - therapy
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehp073

Aims Comparison of intracoronary infusion of bone marrow (BM)-derived unselected mononuclear cells (UNSEL) and selected CD34+CXCR4+ cells (SEL) in patients with acute myocardial infarction (AMI) and reduced