Tracking Fluorescent Polyoxometalates within Cells

Novel organic‐inorganic polyoxometalates (POMs) decorated with covalent fluorescent tags have been designed for cell internalization. Their localization within model HEK cells is readily accomplished by confocal fluorescence microscopy. While cell internalization is dictated by the formation of the...

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Bibliographic Details
Published in:European journal of inorganic chemistry 2018-12, Vol.2018 (46), p.4955-4961
Main Authors: Modugno, Gloria, Fabbretti, Elsa, Dalle Vedove, Andrea, Da Ros, Tatiana, Maccato, Chiara, Hosseini, Hadigheh Sadat, Bonchio, Marcella, Carraro, Mauro
Format: Article
Language:English
Subjects:
Cell membranes
Chirality
Domains
Drug delivery
Fluorescence
Hybrid polyoxometalates
Inorganic chemistry
Polyoxometallates
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Summary:Novel organic‐inorganic polyoxometalates (POMs) decorated with covalent fluorescent tags have been designed for cell internalization. Their localization within model HEK cells is readily accomplished by confocal fluorescence microscopy. While cell internalization is dictated by the formation of the amphiphilic POM‐based nanostructures, their cytoplasmic‐nuclear trafficking appears to be regulated by a subtle interplay of the organic‐inorganic domains of the nanoassemblies which, in turn, impacts their dynamic behavior and capability to interact with cell membranes. Polyoxometalates with appended fluorescent tags form nanoparticles that can internalize into cells, with a localization depending on their composition.
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.201800802