Angiotensin‐converting enzyme insertion/deletion (rs106180) and angiotensin type 1 receptor A1166C (rs106165) genotypes and psoriasis: Correlation with cellular immunity, lipid profile, and oxidative stress markers

Psoriasis is a chronic inflammatory skin condition and angiotensin‐converting enzyme (ACE) is a key circulating enzyme converting angiotensin (Ang) I to the vasoactive peptide Ang II. The exact role of ACE insertion (I)/deletion (D) polymorphism (rs106180) in psoriasis is not clear. We aimed to exam...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2019-02, Vol.120 (2), p.2627-2633
Main Authors: Tanhapour, Maryam, Falahi, Badieh, Vaisi‐Raygani, Asad, Bahrehmand, Fariborz, Kiani, Amir, Rahimi, Zohreh, Vaisi‐Raygani, Ali‐Akbar, Shakiba, Ebrahim, Pourmotabbed, Tayebeh
Format: Article
Language:English
Subjects:
Adhesion tests
Alleles
Ang II type 1 receptor (AGTR1) A1166C variants
Angiotensin
Angiotensin II
angiotensin‐converting enzyme (ACE) I/D genotypes
Antioxidants
Arylesterase
arylesterase (ARE) activity of paraoxonase (PON)
Cardiovascular diseases
Catalase
Cell-mediated immunity
Clonal deletion
Conversion
Disease control
Enzyme-linked immunosorbent assay
Enzymes
Gene deletion
Gene polymorphism
Genotypes
Health risks
Immunity
Inflammation
Insertion
lipid and lipoprotein profiles
Lipids
Liquid chromatography
Malondialdehyde
malondialdehyde (MDA)
Myocardial infarction
Oxidation
Oxidative stress
Patients
Polymerase chain reaction
Polymorphism
Proteins
Psoriasis
Restriction fragment length polymorphism
Risk assessment
Skin
Spectrophotometry
Superoxide dismutase
vascular adhesion protein‐1 (VAP‐1)
Vasoactive agents
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Summary:Psoriasis is a chronic inflammatory skin condition and angiotensin‐converting enzyme (ACE) is a key circulating enzyme converting angiotensin (Ang) I to the vasoactive peptide Ang II. The exact role of ACE insertion (I)/deletion (D) polymorphism (rs106180) in psoriasis is not clear. We aimed to examine whether the ACE I/D and Ang II type 1 receptor (AT1R) A1166C‐polymorphisms (rs106165), lipid profile, and stress oxidative are associated with susceptibility to psoriasis. One hundred patients with psoriasis and 100 sex‐ and age‐matched unrelated healthy controls were recruited for this case‐control study. ACE I/D and AT1R A1166C polymorphisms were identified by the polymerase chain reaction (PCR) and PCR‐restriction fragment length polymorphism, respectively, malondialdehyde (MDA) was detected by the high‐performance liquid chromatography, serum arylesterase (ARE) activity of paraoxonase and catalase activities were detected by the spectrophotometry, superoxide dismutase (SOD) activity and vascular adhesion protein (VAP)‐1 were measured by ELISA. The presence of C allele of AT1R A1166C and I allele of ACE considerably increased the risk of psoriasis by 6.42‐fold (P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.27569