Design, Synthesis and Antitumor Activities of 1,2,3‐triazole‐diethylene Glycol Tethered Isatin Dimers

A series of novel 1,2,3‐triazole‐diethylene glycol tethered isatin dimers were designed, synthesized, and screened for their in vitro antitumor activities in this paper. All dimers showed promising activities against the tested HepG2, Hela, A549, DU145, SKOV3, MCF‐7, and doxorubicin‐resistant MCF‐7...

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry 2018-12, Vol.55 (12), p.2990-2995
Main Authors: Fan, Yi‐Lei, Huang, Zhong‐Ping, Liu, Min
Format: Article
Language:English
Subjects:
Anticancer properties
Antifreeze solutions
Biotechnology
Dimers
Doxorubicin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of novel 1,2,3‐triazole‐diethylene glycol tethered isatin dimers were designed, synthesized, and screened for their in vitro antitumor activities in this paper. All dimers showed promising activities against the tested HepG2, Hela, A549, DU145, SKOV3, MCF‐7, and doxorubicin‐resistant MCF‐7 human cancer cell lines. The most active dimer 7g was >1.55 folds more potent than etoposide against all tested cell lines, warrant further investigation.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3330