In vivo magnetic resonance imaging of injected mesenchymal stem cells in rat myocardial infarction; simultaneous cell tracking and left ventricular function measurement

To determine whether magnetic resonance imaging (MRI) can enable magnetically labeled mesenchymal stem cell (MSC) tracking and simultaneous in vivo functional data acquisition in rat models of myocardial infarction. Superparamagnetic iron oxide-laden human MSCs were injected into rat myocardium infa...

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Published in:The International Journal of Cardiovascular Imaging 2009-04, Vol.25 (Suppl 1), p.99-109
Main Authors: Kim, Young Jin, Huh, Yong-Min, Choe, Kyu Ok, Choi, Byoung Wook, Choi, Eun Jeong, Jang, Yangsoo, Lee, Jae Myun, Suh, Jin-Suck
Format: Article
Language:English
Subjects:
Animals
Cardiac Imaging
Cardiology
Cell Movement
Cells, Cultured
Contrast Media
Dextrans
Disease Models, Animal
Electrocardiography
Ferrosoferric Oxide
Humans
Imaging
Iron
Magnetic Resonance Imaging, Cine
Magnetite Nanoparticles
Male
Medicine
Medicine & Public Health
Mesenchymal Stem Cell Transplantation
Myocardial Infarction - pathology
Myocardial Infarction - physiopathology
Myocardial Infarction - surgery
Myocardium - pathology
Original Paper
Oxides
Radiology
Rats
Rats, Sprague-Dawley
Stroke Volume
Time Factors
Ventricular Function, Left
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cited_by cdi_FETCH-LOGICAL-c369t-1521f008fd913aeda0b0575be41451b00cabb8d04803e2067a1f737024cbd64c3
cites cdi_FETCH-LOGICAL-c369t-1521f008fd913aeda0b0575be41451b00cabb8d04803e2067a1f737024cbd64c3
container_end_page 109
container_issue Suppl 1
container_start_page 99
container_title The International Journal of Cardiovascular Imaging
container_volume 25
creator Kim, Young Jin
Huh, Yong-Min
Choe, Kyu Ok
Choi, Byoung Wook
Choi, Eun Jeong
Jang, Yangsoo
Lee, Jae Myun
Suh, Jin-Suck
description To determine whether magnetic resonance imaging (MRI) can enable magnetically labeled mesenchymal stem cell (MSC) tracking and simultaneous in vivo functional data acquisition in rat models of myocardial infarction. Superparamagnetic iron oxide-laden human MSCs were injected into rat myocardium infarcted by cryoinjury 3 weeks after myocardial infarction. The control group received cell-free media injection. Before injection and for 3 months after, in vivo serial MRI was performed. Electrocardiography-gated gradient echo sequence MRI and cine MRI were performed for in vivo cell tracking and assessing cardiac function using left ventricular ejection fraction (LVEF), respectively. MRI revealed a persistent signal-void representing iron-laden MSCs until ten post-injection weeks. Serial follow-up MRI revealed that LVEF was significantly higher in the MSC injection group than in the control group. We conclude that MRI enables in vivo tracking of injected cells and evaluation of the long-term therapeutic potential of MSCs for myocardial infarction.
doi_str_mv 10.1007/s10554-008-9407-0
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identifier ISSN: 1569-5794
ispartof The International Journal of Cardiovascular Imaging, 2009-04, Vol.25 (Suppl 1), p.99-109
issn 1569-5794
1573-0743
1875-8312
language eng
recordid cdi_proquest_journals_215626921
source Springer Nature
subjects Animals
Cardiac Imaging
Cardiology
Cell Movement
Cells, Cultured
Contrast Media
Dextrans
Disease Models, Animal
Electrocardiography
Ferrosoferric Oxide
Humans
Imaging
Iron
Magnetic Resonance Imaging, Cine
Magnetite Nanoparticles
Male
Medicine
Medicine & Public Health
Mesenchymal Stem Cell Transplantation
Myocardial Infarction - pathology
Myocardial Infarction - physiopathology
Myocardial Infarction - surgery
Myocardium - pathology
Original Paper
Oxides
Radiology
Rats
Rats, Sprague-Dawley
Stroke Volume
Time Factors
Ventricular Function, Left
title In vivo magnetic resonance imaging of injected mesenchymal stem cells in rat myocardial infarction; simultaneous cell tracking and left ventricular function measurement
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