Pre-term pre-labour rupture of membranes: Effect of chorioamnionitis on overall neonatal outcome

Summary Our objective was to evaluate the association between clinical chorioamnionitis following preterm pre-labour rupture of membranes (PPROM) and adverse neonatal outcome. We compared retrospectively, adverse neonatal outcome of singleton pregnancies with documented PPROM who developed chorioamn...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2006-11, Vol.26 (8), p.740-743
Main Authors: Oboro, V. O., Adekanle, B. A., Apantaku, B. D., Onadipe, O. A.
Format: Article
Language:English
Subjects:
Apgar Score
Birth Weight
Chorioamnionitis
Clinical outcomes
Female
Fetal Membranes, Premature Rupture
Gestational Age
Humans
Infant, Newborn
Infant, Newborn, Diseases - etiology
Infections
Male
Obstetrics
Pregnancy
Pregnancy Outcome
Premature labor
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Summary:Summary Our objective was to evaluate the association between clinical chorioamnionitis following preterm pre-labour rupture of membranes (PPROM) and adverse neonatal outcome. We compared retrospectively, adverse neonatal outcome of singleton pregnancies with documented PPROM who developed chorioamnionitis (cases) with those who did not (controls). Our result showed that poor neonatal outcome was significantly associated with chorioamnionitis (34% vs 13%; p = 0.008). This association was found on multiple logistic regression analysis to be independent (p < 0.05) of other risk factors for poor neonatal outcome, viz: latency period (p = 0.002) and gestational age at delivery (p < 0.001). We conclude that chorioamnionitis complicating PPROM worsen neonatal outcome. The implication of this on expectant management of PPROM is discussed.
ISSN:0144-3615
1364-6893
DOI:10.1080/01443610600955776