Efficacy of Inhibitory Control in Antisaccade Task and the Polymorphisms of DRD2 Dopamine Receptor Gene in Schizophrenic Patients

The purpose of this pilot study was to investigate the association of five polymorphic loci of the DRD2 gene ( rs 1799732, rs 1800497, rs 6277, rs 6275, and rs 2242592) with antisaccade task performance in male cohorts of schizophrenic patients ( n = 33) and healthy subjects ( n = 30). The antisacca...

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Bibliographic Details
Published in:Human physiology 2018-11, Vol.44 (6), p.720-724
Main Authors: Storozheva, Z. I., Brodyansky, V. M., Kirenskaya, A. V., Tkachenko, A. A., Kibitov, A. O.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Dopamine D2 receptors
Human Physiology
Life Sciences
Mental disorders
Saccadic eye movements
Schizophrenia
Short Communications
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Summary:The purpose of this pilot study was to investigate the association of five polymorphic loci of the DRD2 gene ( rs 1799732, rs 1800497, rs 6277, rs 6275, and rs 2242592) with antisaccade task performance in male cohorts of schizophrenic patients ( n = 33) and healthy subjects ( n = 30). The antisaccade error rate was analyzed as related to prefrontal inhibitory control. In patients, the increased percent of errors was associated with minor alleles of polymorphisms rs 6277 ( C ), rs 6275 ( T ), and rs 2242592 ( G ), which are supposedly related to the risk of schizophrenia. At the same time, it was found that a decreased error rate in healthy subjects is associated with the C / C variant of rs 6277; no association was observed between polymorphisms rs 6275 and rs 2242592 and task performance.
ISSN:0362-1197
1608-3164
DOI:10.1134/S0362119718050146