Enzymatic markers of cyclosporine nephrotoxicity in patients after renal transplantation

Toxicity of cyclosporine (CsA), an immunosuppressive drug widely used in transplantation, to the transplanted kidney creates a serious side effect. Therefore, searching for sensitive indicators of nephrotoxic action is well worth the effort. In this work we describe the results of estimation of urin...

Full description

Saved in:
Bibliographic Details
Published in:International urology and nephrology 1999, Vol.31 (5), p.727
Main Authors: Marchewka, Z, Kuźniar, J, Długosz, A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Azathioprine - therapeutic use
Creatinine - blood
Cyclosporine - adverse effects
Cyclosporine - therapeutic use
Drug Therapy, Combination
Glucuronidase - urine
Humans
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Kidney Transplantation
Middle Aged
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Toxicity of cyclosporine (CsA), an immunosuppressive drug widely used in transplantation, to the transplanted kidney creates a serious side effect. Therefore, searching for sensitive indicators of nephrotoxic action is well worth the effort. In this work we describe the results of estimation of urine concentration of lysosomal enzymes widely present in the kidney: N-acetyl-beta-D-glucosaminidase (NAG), its isoenzyme NAG-B and beta-glucuronidase (beta-Gr). The studies were conducted in various periods after transplantation of kidneys, on patients under various treatments and receiving different doses of CsA. The results indicate a substantial dependence of the activity of NAG and NAG-B on CsA doses and the period after transplantation. The enzyme proved to be also a sensitive indicator of graft rejection. No such dependence was observed in the case of beta-Gr.
ISSN:0301-1623
1573-2584
DOI:10.1023/A:1007181126577