Successful treatment of a complicated case of neuroleptic malignant syndrome

Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfa...

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Bibliographic Details
Published in:Intensive care medicine 2002-07, Vol.28 (7), p.976-977
Main Authors: LAPPA, A, PODESTA, M, CAPELLI, O, CASTAGNA, A, DI PLACIDO, G, ALAMPI, D, SEMERARO, F
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Antipsychotic Agents - adverse effects
Biological and medical sciences
Dantrolene - therapeutic use
Disseminated Intravascular Coagulation - complications
Drug toxicity and drugs side effects treatment
Female
Fluid Therapy
Humans
Infusions, Intravenous
Italy
Medical sciences
Monoamine Oxidase Inhibitors - administration & dosage
Monoamine Oxidase Inhibitors - adverse effects
Muscle Relaxants, Central - therapeutic use
Neuroleptic Malignant Syndrome - complications
Neuroleptic Malignant Syndrome - drug therapy
Pharmacology. Drug treatments
Rhabdomyolysis - complications
Toxicity: nervous system and muscle
Tranylcypromine - administration & dosage
Tranylcypromine - adverse effects
Treatment Outcome
Trifluoperazine - administration & dosage
Trifluoperazine - adverse effects
Citations: Items that cite this one
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Description
Summary:Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfate, a monoamine oxidase inhibitor, and trifluoperazine (neuroleptic). The case was complicated by rhabdomyolisis and disseminated intravascular coagulation. It was treated successfully with dantrolene sodium and generous fluid therapy without using neuromuscular blocking agents or dopamine agonists.
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-002-1241-6