Asymmetric ring opening of racemic epoxides for enantioselective synthesis of ( S )-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

A novel one-pot epoxide hydrolase/alcohol dehydrogenase/transaminase cascade process for the asymmetric ring opening of racemic epoxides to enantiopure β-amino alcohols is reported. The product ( S )-β-amino alcohols were obtained in 97–99% ee and 79–99% conversion from readily available racemic epo...

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Bibliographic Details
Published in:Catalysis science & technology 2019, Vol.9 (1), p.70-74
Main Authors: Zhang, Jian-Dong, Yang, Xiao-Xiao, Jia, Qiao, Zhao, Jian-Wei, Gao, Li-Li, Gao, When-Chao, Chang, Hong-Hong, Wei, Wen-Long, Xu, Jian-He
Format: Article
Language:English
Subjects:
Alcohol
Alcohol dehydrogenase
Alcohols
Enantiomers
Ring opening
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Summary:A novel one-pot epoxide hydrolase/alcohol dehydrogenase/transaminase cascade process for the asymmetric ring opening of racemic epoxides to enantiopure β-amino alcohols is reported. The product ( S )-β-amino alcohols were obtained in 97–99% ee and 79–99% conversion from readily available racemic epoxides.
ISSN:2044-4753
2044-4761
DOI:10.1039/C8CY02377H